Motor Neuron Disease (MND) is a progressive neurodegenerative disorder characterized by the gradual loss of motor neurons, which are essential for controlling muscle movement. This condition encompasses several diseases, including Amyotrophic Lateral Sclerosis (ALS), Progressive Muscular Atrophy (PMA), and Primary Lateral Sclerosis (PLS). As conventional treatments for Motor Neuron Disease (MND) focus primarily on symptom management and supportive care, many patients seek additional ways to potentially improve their quality of life. One such avenue is exploring natural supplements. The role of natural supplements in the Herbal Treatment for Motor Neuron Disease and evaluates whether these remedies can make a significant difference.