Platelet-Rich Plasma (PRP) hair treatment is generally considered a minimally invasive and well-tolerated procedure, making it a popular choice for individuals seeking non-surgical solutions to hair thinning or hair loss. Since PRP involves injecting the patient’s own platelet-rich plasma into the scalp, understanding the expected comfort level is important for first-time patients. Most patients describe the procedure as mildly uncomfortable rather than painful. The scalp is a sensitive area, and injections may cause a brief stinging or pinching sensation at the injection sites. The discomfort usually lasts only a few seconds per injection. To enhance comfort, clinics often apply a topical numbing cream to the scalp before starting the procedure. This significantly reduces the sensation of pain, allowing the session to be more tolerable. The process begins with a small blood draw, which is similar in sensation to a routine blood test. After processing the blood to concentrate platelets, the injections are administered in multiple areas of the scalp. Some patients report a mild pressure or tingling feeling during the injections, while others experience slight soreness afterward. Any post-treatment tenderness is typically mild and resolves within a day or two. Many patients in Riyadh report that the procedure is highly manageable and that the benefits of PRP—such as improved hair thickness and scalp health—far outweigh the brief discomfort experienced during treatment. For those with lower pain tolerance, the numbing options and careful technique by trained specialists make the procedure comfortable and accessible.