Anticoagulation therapy has become a cornerstone in the management of thromboembolic disorders, including venous thromboembolism (VTE), atrial fibrillation (AF), and mechanical heart valve thrombosis. With an expanding array of patients requiring anticoagulation, there is an ongoing need for safer, more effective, and more convenient treatment options. Over the past decade, the field of anticoagulation has seen significant advancements, primarily with the introduction and evolution of direct oral anticoagulants (DOACs), better patient monitoring technologies, and personalized medicine approaches. This article delves into the latest research, innovations, and therapeutic strategies that are shaping the future of anticoagulation therapy