Mesotherapy\'s science centers on delivering bioactive substances directly into the mesoderm, the middle layer of skin. This targeted approach bypasses the skin\'s outer barrier, maximizing the efficacy of injected ingredients. In Riyadh, this technique is utilized for various aesthetic purposes, leveraging the following principles: Pharmacokinetics: The injected solutions, containing vitamins, minerals, and hyaluronic acid, create a local depot. This allows for sustained release and absorption, optimizing cellular activity. Stimulation of Fibroblasts: Mesotherapy triggers fibroblasts, the cells responsible for collagen and elastin production. This results in improved skin elasticity, reduced wrinkles, and enhanced skin texture. Microcirculation Enhancement: The injections promote increased blood flow to the treated area. This improved circulation delivers oxygen and nutrients, vital for cellular repair and regeneration. Targeted Delivery: By precisely injecting substances into the mesoderm, mesotherapy addresses specific concerns like hyperpigmentation, hair loss, and localized fat deposits, with minimal systemic effects. In Riyadh\'s climate, mesotherapy\'s hydrating and revitalizing effects are particularly beneficial, combating the effects of dry air and sun exposure. The treatment\'s success relies on the practitioner\'s expertise in formulating the appropriate solution and administering injections at the correct depth.