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Xanax XR should be taken exactly as prescribed. The tablets should be swallowed whole and not crushed, chewed, or split unless specifically instructed by your healthcare provider, as doing so may affect how the medication is released. Xanax XR should be taken exactly as prescribed. The tablets should be swallowed whole and not crushed, chewed, or split unless specifically instructed by your healthcare provider, as doing so may affect how the medication is released.