Can You Buy Hydrocodone 10-660mg Online Without an Rx? Yess!! Hydrocodone is a prescription opioid medication used to treat moderate to severe pain. Because it carries significant risks—including dependence, misuse, and overdose—it is regulated as a controlled substance in many countries. A common question people ask is whether it is possible to buy hydrocodone online without a prescription. The short answer is that, in many jurisdictions, including the United States, legitimate pharmacies require a valid prescription before dispensing hydrocodone.